文献类型：期刊文献

中文题名：基于聚肽和海藻酸钠自交联水凝胶的制备与表征

英文题名：Preparation and Characterization of Self-crosslinked Hydrogel Based on Polypeptide and Algniate

作者：王健强[1];肖艳[1]

机构：[1]华东理工大学材料科学与工程学院,上海200237

年份：2018

卷号：31

期号：1

起止页码：69

中文期刊名：功能高分子学报

外文期刊名：Journal of Functional Polymers

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：国家自然科学基金(21674037)

语种：中文

中文关键词：聚肌氨酸-co-聚谷氨酸酰肼;氧化海藻酸钠;水凝胶

外文关键词：PSar-co-PGH;ALG-CHO;hydrogel

摘要：首先以正己胺为引发剂,引发肌氨酸-N-羧酸内酸酐(Sar-NCA)和谷氨酸苄酯-N-内酸酐(BLG-NCA)进行开环聚合制备共聚物,该共聚物经水合肼改性得到无规共聚物聚肌氨酸-co-聚谷氨酸酰肼(PSar-co-PGH);然后用高碘酸钠氧化海藻酸钠制备了氧化海藻酸钠(ALG-CHO);最后将不同浓度的PSar-co-PGH溶液和ALG-CHO溶液进行物理混合,制备了水凝胶。聚合物结构分别采用傅里叶红外光谱(FT-IR)和核磁共振氢谱(1 H-NMR)进行表征;采用扫描电镜、红外光谱和旋转流变仪分别对其凝胶机理和力学性能进行表征。探讨了pH对水凝胶形成的影响。结果表明:成功制备了基于PSar-co-PGH/ALG-CHO的pH响应性水凝胶,水凝胶的储能模量随着PSarco-PGH浓度的增大而增大。
Firstly,polysarcosine-co-poly(L-glutamate-hydrazone)(PSar-co-PGH)was synthesized through ring opening polymerization of sarcosine N-carboxyanhydride(Sar-NCA)andγ-benzyl-L-glutamate N-carboxyanhydride(BLG-NCA)and followed by ester-amide exchange reaction.Then,sodium alginate(ALG)was oxidized by NaIO 4 and oxide sodium alginate(ALG-CHO)was obtained.Finally,hydrogel was prepared by mixing of PSar-co-PGH and ALG-CHO aqueous solution.The structure of polymers was characterized by Nuclear Magnetic Resonance spectroscopy(1H-NMR),Fourier Transform Infrared spectroscopy(FT-IR),and the hydrogel mechanism and properties were characterized by Scanning Electron Microscopy(SEM),FT-IR and rotational rheometer,respectively.The effect of pH on the hydrogel formation was discussed.Results showed that the responsive hydrogel based on PSar-co-PGH/ALG-CHO was successfully prepared,and the store modul of the hydrogel increased with the increase of PSar-co-PGH concentration.