文献类型：期刊文献

英文题名：A hexanuclear Iridium(III) cluster for histidine-induced singlet oxygen and superoxide radicals generation

作者：Yang, Dan[1]; Zhong, Meng[1]; Zhou, Zhiguo[1]; Chen, Xu[2]

机构：[1] College of Chemistry and Material Science, Shanghai Normal University, Shanghai, 200234, China; [2] Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Meilong Road 130, Shanghai, 200237, China

年份：2024

卷号：264

外文期刊名：Polyhedron

收录：EI(收录号：20244417278518)

语种：英文

外文关键词：Iridium - Oxidation

摘要：Photosensitizers (PSs) play key roles in photodynamic therapy (PDT). PDT is typically reliant on the local concentration of oxygen. A big challenge for PSs is to develop oxygen-independent photosensitizers, which can work well in hypoxic tumor microenvironment. In this piece of work, a hexanuclear Ir(III) cluster (Ir6) is highly selective towards histidine and histidine-rich (His-rich) proteins to form mononuclear Ir(III) complexes of [Ir(bpy)2(His)]. After the selective response to histidine or his-rich proteins, [Ir(bpy)2(His)] generates both singlet oxygen(1O2) and superoxide (O2[rad]?). This work opens an avenue for the potential application of Ir6 for type Ι and ΙΙ synergic photodynamic therapy. ? 2024