文献类型：期刊文献

中文题名：2－甲基吲哚－N－烷基化相转移催化机理及其动力学研究

英文题名：Studies of Mechanism and Kinetics of N-Alkylation of 2-Methyl Indole Using Phase Transfer Catalyst

作者：张强[1];邱滔[1];祁国珍[1]

机构：[1]华东理工大学精细化工系

年份：1995

卷号：32

期号：5

起止页码：20

中文期刊名：染料工业

外文期刊名：Dyestuff Industry

基金：国家自然科学基金

语种：中文

中文关键词：甲基吲哚;烷基化;相转移催化;染料;中间体

摘要：应用三乙基等基氯化铵（ＴＥＢＡ）作相转移催化剂，２－甲基吲哚在氢氧化钾溶液和苯中反应，提取到中间体离子对证实了该离子对的存在。实验证明该反应符合Ｍａｋｏｓｚａ提出的相转移催化机理，运用离子选择性电极，对该Ｎ－烷基化反应动力学进行跟踪，实验结果证实了作者推导的动力学方程：在５５℃，反应速度常数Ｋ＝２．８３×１０－３ｍｉｎ－１，活化能Ｅａ＝９９．５ｋＪ／ｍｏｌ．
Triethylbenzyl ammonium chloride was applied as phase transfer catalyst to the Nalkylation of 2-methyl indole under the circumstance of potassium hydroxide and Benzene. The intermediate iron-pair Q+In- (Q+= (C2H5)3, In-= ) was separated and firmed. The reaction proved to conform with Makosza's phase transfer catalysis mechanism. The kinetics of the N-alkylation was tested with ion selective electrode, verifying the equation which was deduced by the author:At 55℃, the kinetic constant was K = 2. 83 ×10-3min-1, and the activation energy was Ea=99.5kJ/mol.