文献类型：期刊文献

中文题名：Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers

作者：Ran Chen[1];Yaping Liu[1];Yanan Jiang[1];Min Sun[2,3];Zhen Fan[1,2];Jianzhong Du[1,2,3,4]

机构：[1]Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China;[2]Department of Gynaecology and Obstetrics,Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Medicine,Tongji University,Shanghai 200434,China;[3]School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;[4]Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China

年份：2025

卷号：1

期号：7

起止页码：584

中文期刊名：Polymer Science & Technology

外文期刊名：高分子科学与技术(英文)

基金：supported by National Natural Science Foundation of China(52222306,22075212,22335005 and 22305177);international scientific collaboration fund of Science and Technology Commission of Shanghai Municipality(23520710900);Innovation Program of Shanghai Municipal Education Commission(2023ZKZD28);the fellowship of China Postdoctoral Science Foundation(2022M720107,GZB20230517,2024T170668);Shanghai“Super Postdoc”Incentive Plan(2022568);Shanghai Rising-Star Program(Sailing,23YF1433000).

语种：英文

中文关键词：biological membrane;membrane-targeted polymers;drug delivery;antitumor;antibacterial

摘要：Membrane structures play a crucial role in biological systems,not only serving as a barrier between cells/organelles and the external microenvironment but also playing key roles in important biological processes such as material exchange,signal transduction,and cell proliferation.With the advancement of related research,membranetargeting strategies have gradually been a focus in modern cancer therapy and antimicrobial studies.Polymer materials show great promise in membrane-targeted therapy due to their excellent biocompatibility,tunability,and functionalization potential.Presented in this review are design strategies for polymer materials targeting cell and organelle membranes.Initially,we introduce the functions and characteristics of tumor cell membranes,organelle membranes,and bacterial cell walls,whose unique physicochemical properties offer potential pathways for targeted therapy.Next,we focus on various strategies for designing polymer materials with membrane targeting features.For instance,by adjusting the charge density and hydrophilicity/hydrophobicity of polymer chains,cationic polymers(e.g.,polyethylenimine and polyamidoamine dendrimers)can leverage electrostatic interactions to disrupt the integrity of the cell membrane,leading to pore formation or structural disruption,which facilitates efficient cytosolic delivery.Thirdly,functionalized polymers can specifically recognize target membranes,thereby reducing side effects.Studies have demonstrated that modified polymers not only facilitate targeted delivery to specific organs but also enhance cellular uptake efficiency by up to 10 times.Finally,we discuss existing challenges and future directions of polymer materials for membrane-targeted therapeutics,aiming to provide insight for advancing membrane-targeted polymers and improving existing treatment strategies for more precise disease management.