文献类型：期刊文献

英文题名：Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses

作者：Hu, Gangfeng[1,2];Wang, Hui[1];Yao, Xiaocong[1];Bi, Dawei[1];Zhu, Gang[1];Tang, Songchao[2];Wei, Jie[2];Yang, Lili[3];Tong, Peijian[4];Xiao, Luwei[4]

机构：[1]First Peoples Hosp Xiaoshang, Hangzhou 311200, Zhejiang, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai, Peoples R China;[3]Second Mil Med Univ, Changzheng Hosp, Dept Orthoped Surg, Shanghai, Peoples R China;[4]Zhejiang Tradit Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China

年份：2014

卷号：9

起止页码：3875

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000340170500003)】；

基金：The authors appreciate financial support by the Hangzhou Science and Technology Bureau (No. 20110733Q30), the National Natural Science Foundation of China (Nos. 81271705, 83171383, and 51173041), the Key Medical Program of Science and Technology Development of Shanghai (No. 12nm0500400, 12441903600), and Key Projects of Basic Research of Science and Technology Development of Shanghai (No. 12JC1411302).

语种：英文

外文关键词：nanofluorapatite; bioactive composites; cell behavior; orthopedic implants

摘要：Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive strength and elastic modulus), hydrophilicity, and antibacterial properties of n-FA/PA12 composite were obviously improved by adding n-FA into PA12 as compared with PA12. In addition, cell proliferation of MC3T3-E1 cells cultured on n-FA/PA12 composite was significantly higher than with PA12, and alkaline phosphatase activity of MC3T3-E1 cells on the n-FA/PA12 composite was expressed at obviously higher levels as compared with PA12. The results suggest that n-FA/PA12 composite could support cell proliferation and differentiation, showing good cytocompatibility. Histological evaluation indicates that n-FA/PA12 composite enhances the efficiency of new bone formation with the introduction of n-FA into PA12, and the quantity of the newly formed bone for n-FA/PA12 composite is significantly higher than with PA12. In conclusion, n-FA/PA12 composite exhibits good biocompatibility and osteogenesis, which might be used for various orthopedic prostheses and dental implants.