文献类型：期刊文献

英文题名：Air-tolerant, ligand-free nickel-catalyzed, manganese-assisted reductive Heck reaction of alkyl/aryl halides with electron-deficient olefins

作者：Xu, Minling[1];Qian, Lijia[1];Zou, Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2023

卷号：547

外文期刊名：MOLECULAR CATALYSIS

收录：;EI(收录号：20232414218483);WOS:【SCI-EXPANDED(收录号:WOS:001029835200001)】；

语种：英文

外文关键词：Nickel catalysis; Conjugate adducts; Reductive Heck reaction; Aryl halides; Air tolerance

摘要：An air-tolerant reductive Heck reaction of alkyl/aryl halides with & alpha;, & beta;-unsaturated esters, nitriles and amides catalyzed by simple nickel bromide has been developed by using manganese as reductant in refluxing acetonitrile. Water plays a double-face role in the catalytic process, hydrolysis of the enolate and/or C-tautomer intermediates to afford the conjugate adducts while suppressing the catalysis at high concentration. The scope and limitations of the nickel-catalyzed manganese-mediated process have been demonstrated by more than 40 examples, showing large steric effects and good functional group compatibility except for reduction-sensitive ones.