文献类型：期刊文献

中文题名：Contributions of distinct prefrontal neuron classes in reward processing

英文题名：Contributions of distinct prefrontal neuron classes in reward processing

作者：Pan XiaoChuan[1];Fan HongWei[2];Wang RuBin[1];Sakagami, Masamichi[2]

机构：[1]E China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai 200237, Peoples R China;[2]Tamagawa Univ, Brain Sci Inst, Machida, Tokyo 1948610, Japan

年份：2014

卷号：57

期号：6

起止页码：1257

中文期刊名：Science China(Technological Sciences)

外文期刊名：SCIENCE CHINA-TECHNOLOGICAL SCIENCES

收录：;EI(收录号：20142817914334);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000336749300027)】；

基金：This work was supported by Grant-in-aid for Scientific Research on Innovative Areas, Grant-in-aid for Scientific Research (A), and Tamagawa Global Center of Excellence, Japan, the National Natural Science Foundation of China (Grant No. 11232005), the Fundamental Research Funds for the Central Universities of China, and Shanghai Pujiang Program (Grant No. 13PJ1402000).

语种：英文

中文关键词：prefrontal cortex;reward;pyramidal neuron;interneuron;monkey;single-unit activity

外文关键词：prefrontal cortex; reward; pyramidal neuron; interneuron; monkey; single-unit activity

摘要：The prefrontal cortex(PFC)is thought to be involved in higher order cognitive functions,such as in working memory,abstract categorization,and reward processing.It has been reported that two distinct neuron classes(putative pyramidal cells and interneurons)in the PFC played different functional roles in neural circuits involved in forming working memory and abstract categories.However,it remains elusive how the two types of neurons process reward information in the PFC.To investigate this issue,the activity of single neurons was extracellularly recorded in the PFC of the monkey performing a reward predicting task.PFC neurons were classified into putative pyramidal cells and interneurons,respectively,based on the waveforms of action potentials.Both the two types of neurons encoded reward information and discriminated two reward conditions(the preferred reward condition vs.the nonpreferred reward condition).However,the putative pyramidal neurons had better and more reliable discriminability than the putative interneurons.Also,the pyramidal cells represented reward information in the preferred reward condition,but not in the nonpreferred reward condition by raising their firing rates relative to the baseline rates.In contrast,the interneurons encoded reward information in the nonpreferred reward condition,but not in the preferred reward condition by inhibiting their discharge rates relative to the baseline rates.These results suggested that the putative pyramidal cells and interneurons had complementary functions in reward processing.These findings may help to clarify individual functions of each type of neurons in PFC neuronal circuits involved in reward processing.
The prefrontal cortex (PFC) is thought to be involved in higher order cognitive functions, such as in working memory, abstract categorization, and reward processing. It has been reported that two distinct neuron classes (putative pyramidal cells and interneurons) in the PFC played different functional roles in neural circuits involved in forming working memory and abstract categories. However, it remains elusive how the two types of neurons process reward information in the PFC. To investigate this issue, the activity of single neurons was extracellularly recorded in the PFC of the monkey performing a reward predicting task. PFC neurons were classified into putative pyramidal cells and interneurons, respectively, based on the waveforms of action potentials. Both the two types of neurons encoded reward information and discriminated two reward conditions (the preferred reward condition vs. the nonpreferred reward condition). However, the putative pyramidal neurons had better and more reliable discriminability than the putative interneurons. Also, the pyramidal cells represented reward information in the preferred reward condition, but not in the nonpreferred reward condition by raising their firing rates relative to the baseline rates. In contrast, the interneurons encoded reward information in the nonpreferred reward condition, but not in the preferred reward condition by inhibiting their discharge rates relative to the baseline rates. These results suggested that the putative pyramidal cells and interneurons had complementary functions in reward processing. These findings may help to clarify individual functions of each type of neurons in PFC neuronal circuits involved in reward processing.