文献类型：期刊文献

中文题名：pH敏感性叶酸修饰羧甲基壳聚糖纳米粒子作为紫杉醇载体的研究

英文题名：Study on pH-Sensitive Folate Modified Carboxymethyl Chitosan Nanoaparticles for Paclitaxel Delivery

作者：张琳琳[1];郎美东[1]

机构：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237

年份：2013

卷号：26

期号：2

起止页码：142

中文期刊名：功能高分子学报

外文期刊名：Journal of Functional Polymers

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家自然科学基金(20804015);中央高校基本科研基金(WD0913008;WD1014036)

语种：中文

中文关键词：羧甲基壳聚糖;叶酸;紫杉醇;pH敏感性;靶向

外文关键词：carboxymethyl chitosan; folate; paclitaxel; pH-sensitivity; targeting the nanoparticles with existence of folate on

摘要：将活化的叶酸分子连接到O-羧甲基壳聚糖(O-CMCS)上。以CaCl2为交联剂,通过离子交联法制备叶酸修饰的O-CMCS纳米粒子(FCC NPs),并开展了从FCC NPs作为抗癌药物紫杉醇(PTX)载体的研究。结果表明:FCC NPs呈球形,粒子大小约190nm,对PTX的载药量和包封率均受PTX加入量的影响。该纳米粒子对药物的释放具有较好的pH敏感性,能够增强PTX在癌细胞处的富集。同时,该纳米粒子无细胞毒性,纳米粒子表面由于叶酸的存在使其具有较好的细胞靶向性,且载药纳米粒子对癌细胞生长具有良好的抑制作用。
The activated folate molecular was conjugated to O-carboxymethyl chitosan（O-CMCS）, and the nanoparticles were prepared by ionic cross-linking method using CaC12 as the cross-linked agent, then the nanoparticles used as the carrier of paclitaxel （PTX） were studied. Results showed that the nanoparticles were spherical and the particle size was about 200 nm. The drug loading content （DLC） and encapsulation efficiency （EE） were both effected by adding PTX. The nanoparticles had a good pH-sensitivity to the drug release which could enhance the PTX enrichment in cancer cells. Meanwhile, no toxicity on normal cells, had a good targeting ability to cancer cells as the O-CMCS and also had a good growth inhibition effect on cancer cells.