文献类型：专利

英文题名：Oxygen free radical-based targeting functional material useful for treating e.g. tumor sites, inflammatory sites, atherosclerosis, peptic ulcer, brain reperfusion injury, primary glomerular disease, diabetes mellitus or bronchial asthma

作者：ZHAO H;TAO L;LAN M;YUAN H;LIU X;GONG W

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN106267223-A

申请日：2015-05-11

公开日：2017-01-04

语种：英文

收录：DERWENT

摘要：NOVELTY - Oxygen free radical-based targeting functional material, where the functional material having tumor targeting function is claimed. USE - The targeting functional material is useful: for treating tumor sites; for treating inflammatory sites, atherosclerosis or gastritis; for treating peptic ulcer or brain reperfusion injury; for treating primary glomerular disease or diabetes mellitus; and for treating bronchial asthma, emphysema or tremor paralysis (all claimed). ADVANTAGE - The targeting functional material can be easily tracked by EPR monitoring, is easy to save, can also connected with variety of nano-carriers, and has simultaneous targeting and tumor detection properties. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing oxygen free radical-based targeting functional material comprising taking carrier and then carrying out certain method for surface modifying, then carrying out chemical reaction of surface modified carrier special group of formula A-X (I) with R-TEMPO or its derivatives, linking by chemical bonds, constituting anti-tumor drug carrier containing exposed TEMPO group outside to obtain final product of formula A-TEMPO (II), where the certain method refers molecular self-assembly method, high-temperature precipitation, thermal decomposition, ultrasonic method, the carrier (A) of the antitumor drug is nano micelle having particle size of 1-1000 nm, the nanoparticles (having a particle size of 1-1000 nm), nano-vesicles (having particle size of 1-1000 nm), nanotubes (having particle size of 1-1000 nm), and/or after some modification, maintains nature of drug itself, the surface-modified carrier is carrier containing fluorescent label (e.g. quantum dot (QDS), fluorescein isothiocyanate (FITC), hydroxyfluorescein (FAM), tetrachlorofluorescein (TET) or cyanine dyes (cy5.5), the specific groups of the surface-modified carrier are amino, carboxy, and/or N-methacryloyloxysuccinimide (-NAS) group, the TEMPO or its derivatives are aminated, carboxylated or chemically modified TEMPO or its derivatives, the TEMPO group is exposed to the outside of the carrier in order to make it better and tumor and its environmental exposure to achieve better targeting effect, the chemical reaction is method in which a surface-modified nanocarrier can be linked to TEMPO or derivative by a chemical bond, and does not change the original material and ligand properties of the chemical reaction, e.g. acid amine condensation reaction, and/or amide condensation reaction. X = carboxy group, amino group or N-methacryloyloxysuccinimide (-NAS); and R = amino group or carboxy group. Provide that: X can easily be linked to different functional ligand, e.g. folic acid, fluorescein or nitroxides.