文献类型：期刊文献

英文题名：Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering

作者：Zhang, Xuewei[1];Chen, Xi[1];Hong, Hua[1];Hu, Rubei[1];Liu, Jiashang[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Engn Res Ctr Biomat,Minist Educ, Key Lab Ultrafine Mat,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：10

起止页码：15

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000743258200002)】；

基金：This work was primarily leveraged by National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), National Key R&D Program of China (No. 2018YFC1105700), and the Fundamental Research Funds for the Central Universities (No. JKVD12001002, JKD01211612). Any opinions, findings, conclusions, or recommendations expressed herein are those of the author(s).

语种：英文

外文关键词：Decellularization; ECM; 3D scaffolds; Tissue regeneration; Recellularization

摘要：The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the difficulties in overcoming the immunogenicity, simulating in-vivo microenvironment, and performing mechanical or biochemical properties similar to native organs/tissues. Fortunately, the emergence of decellularized extracellular matrix (dECM) scaffolds provides an attractive way to overcome these hurdles, which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components. The consequent cell-seeded construct based on dECM scaffolds, especially stem cell-recellularized construct, is considered an ideal choice for regenerating functional organs/tissues. Herein, we review recent developments in dECM scaffolds and put forward perspectives accordingly, with particular focus on the concept and fabrication of decellularized scaffolds, as well as the application of decellularized scaffolds and their combinations with stem cells (recellularized scaffolds) in tissue engineering, including skin, bone, nerve, heart, along with lung, liver and kidney.