文献类型：期刊文献

英文题名：Stress Relaxation-Mediated Corneal Epithelial Repair Enabled by a Dynamic Hydrogel With Controlled Drug Release

作者：Yang, Haochen[1,2];Chen, Linjie[1,2];Ma, Yingchao[1,2];Li, Ziyuan[1,2];Zhang, Junji[1,2];Wang, Chen[1,2,3]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Inst Fine Chem,Frontiers Sci Ctr Materiobiol & Dyn, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai, Peoples R China;[3]East China Normal Univ, Sch Chem & Mol Engn, Shanghai, Peoples R China

年份：2026

卷号：21

期号：2

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20255119735040);WOS:【SCI-EXPANDED(收录号:WOS:001639634600001)】；

基金：This work is supported by the National Key R&D Program of China (2023YFF0722600), NSFC (22122803, 22378121, 22105070, and 32350018), Science and Technology Commission of Shanghai Municipality (24DX1400200), and the Fundamental Research Funds for the Central Universities (222201717003). Junji Zhang acknowledges Shanghai Natural Science Foundation Project (23ZR1479500 and 23JC1401700). Ziyuan Li acknowledges Shanghai Sailing Program (20YF1410300).

语种：英文

外文关键词：cell migration; double crosslinking; dynamic hydrogel; viscoelasticity

摘要：Facilitating cell migration to injury sites is critical for repair. This process is significantly influenced by mechanotransduction, where cells sense and dynamically respond to extracellular mechanical cues, especially viscoelasticity. However, within viscoelastic microenvironments, the relative dominance of stiffness versus stress relaxation in directing migration remains unresolved. This necessitates biomaterials enabling independent tuning of viscoelasticity. In this study, we engineered a transparent hydrogel platform by synergistically crosslinking oxidized hyaluronic acid (oxi-HA) and gelatin methacryloyl (GelMA) via covalent bonds and dynamic Schiff base linkages. Precise modulation of the bond ratios achieved decoupled control over stiffness and stress relaxation. In vitro studies assessing fibroblast and epithelial cell migration on hydrogels with varying stiffness (2.3-11.5 kPa) and relaxation times (2.3-17.2 s) revealed substrate stress relaxation as the dominant cue governing migration. Furthermore, the cornea-like optical transparency (>90%), through the optimized formular, was achieved, and the hydrogel's drug release capacity was evaluated.