文献类型：期刊文献

英文题名：Carbonyl-bridged trifluoromethyl pyridine derivatives for pest control and mechanistic investigations

作者：Sheng, Zhubo[1];Deng, Jie[1];Yuan, Qinglong[1];Fu, Wen[1,5];Xu, Zhiping[1];Li, Xiaoyan[6];Li, Zhong[1,2];Shao, Xusheng[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China;[5]Guizhou Univ, Natl Key Lab Green Pesticide, Guiyang 550025, Guizhou, Peoples R China;[6]China Agr Univ, Yantai Inst, Coll Humanities & Econ Management, Yantai 264670, Shandong, Peoples R China

年份：2026

卷号：5

期号：1

起止页码：33

外文期刊名：ADVANCED AGROCHEM

收录：WOS:【ESCI(收录号:WOS:001721266500001)】；

基金：This work was financially supported by National Natural Science Foundation of China (32472610, 32402439, 32072441) , National Key Research and Development Program of China (2018YFD0200100) , Innovation Program of Shanghai Municipal Education Commission (2017 01 07 00 02 E00037) , Tobacco and Health funding program (2022539200340111) , Shanghai Frontiers Science Center of Opto-genetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) and the project of National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University (SKL-GPL-KF-202405) .

语种：英文

外文关键词：TFMP; Carbonyl-bridged; Structure-activity relationships; Molecular docking; Calcium ion

摘要：Trifluoromethyl pyridine (TFMP) motif is commonly discovered in structures of active pharmaceuticals. Flonicamid, characterized by the TFMP moiety, is well known as a prodrug in the knockdown of pests. The azobenzene-modified TFMP derivatives have been previously reported with excellent insecticidal activities. Herein, twenty-one TFMP derivatives were designed by the introduction of carbonyl-bridged aryl groups and synthesized via a one-step synthesis using Flonicamid as the starting material. The structure-activity relationships of these compounds were well analyzed and discussed. A molecular docking study and calcium ion concentration analysis indicated that compound FC13 could have interacted with the nicotinamidase enzyme, which further influenced the Ca2+ influx.