文献类型：期刊文献

英文题名：Formation of Dihydronaphthalenes via Organocatalytic Enatioselective Michael-Aldol Cascade Reactions with Arylalkanes

作者：Li, Xiangmin[1,2];Wang, Sinan[1,2];Li, Tengfei[1,2];Li, Jian[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2013

卷号：15

期号：22

起止页码：5634

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327175500006)，CCR-EXPANDED(收录号:WOS:000327175500006)】；

基金：Financial support of this research from the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (No. 201226, H.L.), Shanghai Pujiang Scholarship Program (No. 11PJ1411900, H.L.), the National Science Foundation of China (No. 21372073, W.W.), the Fundamental Research Funds for the Central Universities and East China University of Science and Technology (start-up fund, H.L. and W.W.), and the National Science Foundation (CHE-1057569, W.W.) is gratefully acknowledged.

语种：英文

摘要：An organocatalytic highly enantioselective Michael-aldol cascade access to valuable chiral dihydronaphthalenes has been realized. Notably, the strategy via activation of nucleophilic alkyl chains by introducing nitro, chloro, or CF3 group(s) at the ortho- and/or para-position(s) on an aromatic ring renders them readily deprotonated to produce highly reactive nulecophilic species in the cascade process under mild conditions.