文献类型：期刊文献

英文题名：7-Amino coumarin based fluorescent phototriggers coupled with nano/bio-conjugated bonds: Synthesis, labeling and photorelease

作者：Lin, Qiuning[1];Bao, Chunyan[1];Fan, Guanshui[1];Cheng, Shuiyu[1];Liu, Hui[1];Liu, Zhenzhen[1];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2012

卷号：22

期号：14

起止页码：6680

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY

收录：;EI(收录号：20121314898701);WOS:【SCI-EXPANDED(收录号:WOS:000301459500026)】；

基金：This work was supported by NSFC (2117308), "Chen Guang'' project (09CG25), Shanghai Sci. Tech. Comm. (11JC1403300), Shanghai Rising-star program "10QA1401600'' and Fundamental Research Funds for the Central University.

语种：英文

外文关键词：Conjugated polymers - Silica nanoparticles

摘要：By several synthetic pathways, we designed and synthesized a new series of unsymmetrical substituted 7-amino coumarin-based phototriggers with various nano/bio-conjugated bonds. The photophysical properties of most of the substituted coumarin-based phototriggers, except for compound P9 with maleimide group, showed no significant change compared with that of 7-(diethylamino)-4-( hydroxylmethyl) coumarin (DEACM-OH, the reported symmetric substituted 7-amine coumarin based phototrigger). Four compounds (P2, P4, P9, 14) were successfully conjugated with typical carriers such as mesoporous silica nanoparticles, biocompatible polymer PEG and common protein BSA, respectively. The efficient photorelease of ibuprofen (IBU) in the model cargo delivery system of MD4 confirmed that our designed phototriggers could serve well as a photo-cage for bioactive molecules and the release can be regulated precisely by manipulating the external irradiation conditions. All the results hinted at the superiority of using these coumarin functional compounds for photo-regulated release in biotechnology and biomedical areas.