文献类型：期刊文献

中文题名：Near-infrared light switching nitric oxide nanogenerator with“linkage mechanism”for tumor targeting multimodal synergistic therapy

作者：Wei Zhang[1];Qize Xuan[1];Qi Zhang[1];Tong Wang[1];Chen Wang[2];Hui Li[2];Chao Chen[1,2];Ping Wang[3]

机构：[1]State Key Laboratory of Bioreactor Engineering,Biomedical Nanotechnology Center,School of Biotechnology,East China University of Science and Technology,Shanghai,200237,China;[2]Institute for Environmental Pollution and Health,School of Environmental and Chemical Engineering,Shanghai University,Shanghai,200444,China;[3]Department of Bioproducts and Biosystems Engineering,University of Minnesota,St Paul,MN,55108,USA

年份：2023

卷号：66

期号：2

起止页码：586

中文期刊名：Science China Chemistry

外文期刊名：中国科学（化学英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Natural Science Foundation of China(21908059);the China Postdoctoral Science Foundation(2019M651419);the Shanghai Sailing Program(19YF1410900,21YF1451700);the Natural Science Foundation of Shanghai(22ZR1415400);the Fundamental Research Funds for the Central Universities(22221818014);the Shanghai Post-doctoral Excellence Program(2018011);the Foundation of State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology,Shandong Academy of Sciences(GZKF202031);the Open Funding Project of the State Key Laboratory of Bioreactor Engineering。

语种：英文

中文关键词：NO generator;NIR-trigger NO release;linkage mechanism;gas therapy;targeted synergistic therapy

摘要：Gaseous therapy based on nitric oxide(NO),as a potential anti-tumor treatment strategy,has attracted great attention,but the targeted and controlled gas release in the tumor site still remains a challenge.In addressing these difficulties,a near-infrared(NIR)light-triggered NO release nanogenerator with a“linkage mechanism”was designed on the basis of sodium nitroprussidedoped mesoporous Prussian blue nanoparticles,in which the outer structure was modified with p H-sensitive gatekeeper chitosan and tumor-targeting agent folic acid.The“linkage mechanism”can achieve precise release of NO under the control of photothermal effect at tumor site,which can couple photothermal therapy and gas therapy to address the premature release of gas during transportation.Meanwhile,the amount of released gas can be controlled by adjusting the irradiation time and laser intensity.Furthermore,as-fabricated nanocomposites hold high photothermal conversion efficiency under NIR laser irradiation,resulting in the on-demand release of NO and chemotherapy drugs.The released NO can inhibit the expression of hypoxiainducible factorα(HIF-1α)and alleviate the hypoxic tumor microenvironment,thereby enhancing the efficacy of chemotherapy.Moreover,in vitro and in vivo experiments exhibited remarkable antitumor efficiency,and the synergistic gas/chemo/photothermal therapy of deep tumors was achieved.These findings indicate an effective strategy to stimulate further the development of deep tumor therapy,which may provide new insights into other NO-related medical applications.