文献类型：期刊文献

英文题名：Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process

作者：Lin, Qiuning[1];Huang, Qi[1];Li, Chunyan[2,3];Bao, Chunyan[1];Liu, Zhenzhen[1];Li, Fuyou[2,3];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China;[3]Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China

年份：2010

卷号：132

期号：31

起止页码：10645

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20103213142912);WOS:【SCI-EXPANDED(收录号:WOS:000280692200010)】；

语种：英文

外文关键词：Controlled drug delivery - Silica nanoparticles - Targeted drug delivery - Two photon processes - Biocompatibility - Fluorescence imaging - Medical applications - Photons

摘要：An excellent mesoporous silica nanoparticle (MSN) based drug deliver system (DDS) was reported for regulated anticancer drug release upon the irradiation of either one- or two-photon excitation. In this system, the coumarin grafted on MSN acted as both the "phototrigger for the drug release and fluorescence group for cell luminescence imaging. External light manipulations such as changing irradiation wavelength, intensity, and time can regulate the release of the anticancer drug precisely. Biological studies in vitro suggest that the drug carrier can effectively deliver the anticancer drug into intracellular environs and, hence, promote the drug action to kill the cancer cells upon irradiation. We envision that the good biocompatibility, cellar uptake property, and efficient photoregulated drug release will be of great benefit to future controlled release in vivo biomedical applications.