文献类型：期刊文献

英文题名：Enantiomeric separation of tryptophan via novel chiral polyamide composite membrane

作者：Peng, Xinwei[1];Wei, Yongming[1];Peng, Yangfeng[1];Zhao, Hongliang[1];Tong, Tianzhong[1];He, Quan[2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Dalhousie Univ, Fac Agr, Dept Engn, Truro, NS, Canada

年份：2024

卷号：36

期号：5

外文期刊名：CHIRALITY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001258430000001)】；

基金：The authors are thankful for the financial support provided by the National Natural Science Foundation of China (21978082).

语种：英文

外文关键词：chiral composite membrane; enantioseparation; interfacial polymerization; tryptophan; beta-cyclodextrin

摘要：The separation of chiral drugs continues to pose a significant challenge. However, in recent years, the emergence of membrane-based chiral separation has shown promising effectiveness due to its environmentally friendly, energy-efficient, and cost-effective characteristics. In this study, we prepared chiral composite membrane via interfacial polymerization (IP), utilizing beta-cyclodextrin (beta-CD) and piperazine (PIP) as mixed monomers in the aqueous phase. The chiral separation process was facilitated by beta-CD, serving as a chiral selective agent. The resulting membrane were characterized using SEM, FT-IR, and XPS. Subsequently, the chiral separation performance of the membrane for DL-tryptophan (Trp) was investigated. Lastly, the water flux, dye rejection, and stability of the membrane were also examined. The results showed that the optimized chiral PIP0.5 beta-CD0.5 membrane achieved an enantiomeric excess percentage (ee%) of 43.0% for D-Trp, with a solute flux of 66.18 nmolcm-2h-1, and maintained a good chiral separation stability. Additionally, the membrane demonstrated positive performance in the selective separation of mixed dyes, allowing for steady operation over a long period of time. This study offers fresh insights into membrane-based chiral separations. A novel chiral polyamide composite membrane successfully and selectively separates tryptophan enantiomers. image