文献类型：期刊文献

英文题名：Tissue engineering scaffolds of mesoporous magnesium silicate and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) composite

作者：He, Dawei[1];Dong, Wei[2];Tang, Songchao[3];Wei, Jie[3];Liu, Zhenghui[3];Gu, Xiaojiang[1];Li, Ming[1];Guo, Han[4];Niu, Yunfei[1]

机构：[1]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China;[2]Second Mil Med Univ, Fac Hlth Serv, Shanghai 200433, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China

年份：2014

卷号：25

期号：6

起止页码：1415

外文期刊名：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

收录：;EI(收录号：20142817913646);WOS:【SCI-EXPANDED(收录号:WOS:000336904200003)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (No. 81000799, 81271705, 31100680 and 51173041), Nano special program of Science and Technology Development of Shanghai (No. 12nm0500400), and the Key Medical Program of Science and Technology Development of Shanghai (No. 12441902800, 12441903600).

语种：英文

外文关键词：Magnesium compounds - Organic solvents - Silicates - Biocompatibility - Bone - Ethylene glycol - Biodegradation - Scaffolds (biology) - Polyols

摘要：Mesoporous magnesium silicate (m-MS) and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) composite scaffolds were fabricated by solvent-casting and particulate leaching method. The results suggested that the incorporation of m-MS into PCL-PEG-PCL could significantly improve the water adsorption of the m-MS/PCL-PEG-PCL composite (m-MPC) scaffolds. The in vitro degradation behavior of m-MPC scaffolds were determined by testing weight loss of the scaffolds after soaking into phosphate buffered saline (PBS), and the result showed that the degradation of m-MPC scaffolds was obviously enhanced by addition of m-MS into PCL-PEG-PCL after soaking for 10 weeks. Proliferation of MG63 cells on m-MPC was significantly higher than MPC scaffolds at 4 and 7 days. ALP activity on the m-MPC was obviously higher than MPC scaffolds at 7 days, revealing that m-MPC could promote cell differentiation. Histological evaluation showed that the introduction of m-MS into PCL-PEG-PCL enhanced the efficiency of new bone formation when the m-MPC scaffolds implanted into bone defect of rabbits. The results suggested that the inorganic/organic composite of m-MS and PCL-PEG-PCL scaffolds exhibited good biocompatibility, degradability and osteogenesis.