文献类型：期刊文献

英文题名：Gold(I)-promoted synthesis of a β-(1,3)-glucan hexadecasaccharide via the highly convergent strategy

作者：Wang, Zixuan[1];Hua, Qingting[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：482

外文期刊名：CARBOHYDRATE RESEARCH

收录：;EI(收录号：20192707138045);WOS:【SCI-EXPANDED(收录号:WOS:000487200000004)】；

基金：Financial support from the National Thousand Young Talents Program (Y100-4Q-1701, YC0140103), the National Natural Science Foundation of China (21871081) and the Fundamental Research Funds for the Central Universities (50321031916002, 22221818014) is gratefully acknowledged.

语种：英文

外文关键词：Glycosylation; Polysaccharide; Gold; Glycosyl ortho-hexynylbenzoate; beta-(1,3)-glucan

摘要：Elucidation of the structure-activity relationships of beta-(1,3)-glucans is hampered by the difficulty to isolate the beta-(1,3)-glucan polysaccharides from natural sources. We describe a gold(I)-promoted approach for the efficient assembly of a beta-(1,3)-glucan hexadecasaccharide via the orthogonal and consecutive activation of thioglycosides and glucosyl ortho-hexynylbenzoates in a highly convergent manner. The synthetic hexadecasaccharide serves as the basis for further evaluation of their biological functions.