文献类型：期刊文献

英文题名：Self-assembly behavior of rod-coil-rod polypeptide block copolymers

作者：Zhuang, Zeliang[1];Cai, Chunhua[1];Jiang, Tao[1];Lin, Jiaping[1];Yang, Chaoying[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat,Shanghai Key Lab Adv Polyme, Shanghai 200237, Peoples R China

年份：2014

卷号：55

期号：2

起止页码：602

外文期刊名：POLYMER

收录：;EI(收录号：20140517242792);WOS:【SCI-EXPANDED(收录号:WOS:000331154700018)】；

基金：This work was supported by National Natural Science Foundation of China (21234002, 50925308), Key Grant Project of Ministry of Education (313020) and National Basic Research Program of China (No. 2012CB933600). Support from projects of Shanghai municipality (10GG15 and 12ZR1442500) and Fundamental Research Funds for the Central Universities (WD1214008) are also appreciated.

语种：英文

外文关键词：Polypeptide; Self-assembly; Rod-coil block copolymer

摘要：Self-assembly behavior of rod coil rod poly(gamma-benzyl-L-glutamate)-b-poly(ethylene glycol)-b-poly(gamma-benzyl-L-glutamate) (PBLG-b-PEG-b-PBLG) triblock copolymers with various PBLG block lengths in aqueous solution was investigated. The PBLG-b-PEG-b-PBLG triblock copolymers are able to self-assemble into vesicles when PBLG block length is relatively short. Meanwhile, the initial polymer concentration was found to have influence on the self-assembly. Giant vesicles can be observed when the initial concentration is high. Dissipative particle dynamics (DPD) simulations about the vesicles revealed that the rigid rod blocks could be aligned parallelly with each other to form the monolayer vesicles wall. When the PBLG block length in the PBLG-b-PEG-b-PBLG triblock copolymers increases, the aggregate morphologies were observed to transform from vesicles to spherical micelles. Based on the experimental and simulation results, we proposed a possible mechanism of the morphological transitions of the rod-coil-rod triblock copolymer aggregates. (C) 2013 Elsevier Ltd. All rights reserved.