文献类型：期刊文献

英文题名：Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media

作者：Yu, Hui-Lei[1];Xu, Jian-He[1];Wang, Yu-Xiao[1];Lu, Wen-Ya[2];Lin, Guo-Qiang[2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2008

卷号：10

期号：1

起止页码：79

外文期刊名：JOURNAL OF COMBINATORIAL CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000252409800013)】；

语种：英文

摘要：Glycoconjugates can be artificially synthesized by combinatorial biocatalysis. An example is given in this paper describing the construction of glycoconjugates array by using glycosidase and lipase in nonaqueous media. This array was started from glucose, with three aryl alcohols as the aglycone moiety of glycosides and five acids or esters as acyl donors for combinatorial acylation of glycosides, affording a three-dimensional array containing about 30 members with diverse structures. The array would be more abundant if more aglycones and acyl donors with other structures were filled in. Indeed, diverse classes of carbohydrates besides glucose can also be employed for generating diverse glycoconjugates due to their different roles in numerous physiological responses. The composition and distribution of the demonstration glycoconjugates array was detected and evaluated by HPLC-MS with electrospray ionization. And also, the distribution of the artificial array can be adjusted by changing the molar ratio of the auxiliary materials.