文献类型：期刊文献

英文题名：Ultrasound-Triggered Smart Drug Release from Multifunctional Core-Shell Capsules One-Step Fabricated by Coaxial Electrospray Method

作者：Jing, Yujia[1];Zhu, Yihua[1];Yang, Xiaoling[1];Shen, Jianhua[1];Li, Chunzhong[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2011

卷号：27

期号：3

起止页码：1175

外文期刊名：LANGMUIR

收录：;EI(收录号：20111213771695);WOS:【SCI-EXPANDED(收录号:WOS:000286485600045)】；

基金：This work was supported by the National Natural Science Foundation of China (20925621, 20976054), the Key Project of Science and Technology for Ministry of Education (107045), the Innovation Program of Shanghai Municipal Education Commission (09ZZ58), the Fundamental Research Funds for the Central Universities, the Program for Changjiang Scholars and Innovative Research Team in University (IRT0825), and the Shanghai Leading Academic Discipline Project (project number: B502).

语种：英文

外文关键词：Fluorescence imaging - Shells (structures) - Targeted drug delivery - Fabrication - Titanium dioxide - Magnetite - Controlled drug delivery - Semiconductor quantum dots

摘要：Multifunctional core-shell capsules that triggered release by ultrasound stimulus were one-step fabricated by the coaxial electrospray method. The TiO2 shell suppressed the initial burst release of the paclitaxel. Fe3O4 and graphene quantum dots inside the oil core functioned successfully for magnetic targeting and fluorescence imaging, respectively. Paclitaxel was trigger released when the dual layer of titania shell cracked under the ultrasound stimulation, and the releasing profile could be controlled by the length of applied ultrasound time.