文献类型：期刊文献

英文题名：A new ganoderic acid from Ganoderma lucidum mycelia

作者：Wang, Jia-Le[1];Li, Ying-Bo[2];Liu, Ru-Ming[2];Zhong, Jian-Jiang[1]

机构：[1]Shanghai Jiao Tong Univ, Key Lab Microbial Metab, Minist Educ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2010

卷号：12

期号：8

起止页码：727

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000280817100016)】；

基金：Financial support from the National Natural Science Foundation of China (NSFC Project Nos 20776084 and 30821005), the National High Technology R&D Program (863 Project No. 2007AA021506), Shanghai Science & Technology Commission (Project No. 08DZ1971900), and the Shanghai Leading Academic Discipline Project (Project Nos B203 and B505) are gratefully acknowledged. The authors express their appreciation to Prof. Shuang-Jun Lin and Dr Jie-Li Wu for their kind help in spectral analysis.

语种：英文

外文关键词：Ganoderma lucidum; Ganodermataceae; 7-O-ethyl GA-O; ethoxyl; cytotoxicity

摘要：A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3,15,22-triacetoxy-7-ethoxy-5-lanost-8,24E-dien-26-oic acid. The new compound was found to contain a rare ethoxyl group at C-7. In addition, its cytotoxicity against 95D and HeLa human cancer cell lines was also evaluated.