文献类型：期刊文献

中文题名：纳米明胶粒子的制备及其表面改性

英文题名：Preparation of Gelatin Nanoparticles by Desolvation and Surface Modification

作者：丁素丽[1];朱以华[1];杨晓玲[1]

机构：[1]华东理工大学超细材料制备与应用教育部重点实验室,上海200237

年份：2004

卷号：30

期号：5

起止页码：523

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：2004498707042);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(20276019);国家863计划(2002AA302208);上海市纳米专项(0243nm069)资助项目

语种：中文

中文关键词：纳米明胶粒子;单凝聚;聚电解质;吸附

外文关键词：gelatin nanoparticle; single-desolvation; polyelectrolate; adsorption

摘要：用改进的二次单凝聚法制备了粒径在100nm左右的纳米明胶粒子,并考察了凝聚剂用量,pH值,胶凝时间和固化时间等因素的影响。得到最佳的工艺条件为:凝聚剂的体积分数为0.444,pH值为3.8,胶凝时间为10min,固化时间为25min。通过吸附聚对苯乙烯磺酸钠(PSS),对明胶粒子进行表面改性,使其表面带有负电荷,用反滴定的方法测得最大吸附量为每克明胶粒子吸附8.23mgPSS,为后期在表面吸附带有正电荷的药物打下了基础。
Gelatin nanopaticles about 100 nm in diameter were prepared by two-step single-desolvation improved, and the influence of the content of flocculant, pH value, desolvating and hardening times was investigated, respectively. The optimum conditions for the preparation are as follows: volume fraction of flocculant, 0.444; pH value, 3.8; desolvating time, 10 min; and hardening time, 25 min. The surface of gelatin particles is modified by adsorbing sodium poly(styrene sulfonate)(PSS), which made it negatively charged, and the amount of adsorbed PSS per gelatin nanoparticle determined by titrating in reverse is 8.23 mg. It may be provide the base of adsorbing medicines with positive charge.