文献类型：期刊文献

英文题名：Silica-based 2-(N,N-dimethylamino)-1,3-propanediol hydrophilic interaction liquid chromatography stationary phase for separating cephalosporins and carbapenems

作者：Yin, Wei[1];Cheng, Lingping[1];Chai, Huihui[1];Guo, Ruiqiang[1];Liu, Renhua[1];Chu, Changhu[1];Palasota, John A.[2];Cai, Xiaohui[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Univ St Thomas, Dept Chem & Phys, Houston, TX 77006 USA

年份：2015

卷号：407

期号：20

起止页码：6217

外文期刊名：ANALYTICAL AND BIOANALYTICAL CHEMISTRY

收录：;EI(收录号：20152300902417);WOS:【SCI-EXPANDED(收录号:WOS:000358371200034)】；

基金：This research was sponsored by National Natural Science Foundation of China (No. 21372081, No. 21172072)

语种：英文

外文关键词：Click 2-(N,N-dimethylamino)-1,3-propanediol; Stationary phase; HILIC; Nucleosides and bases; Cephalosporins and carbapenems

摘要：A silica-based stationary phase bearing both hydrophilic hydroxyl and amino groups was developed by covalently bonding a small molecular N,N-dimethylamino 1,3-propanediol moiety onto silica beads via copper(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This new stationary phase showed good HILIC characteristics and high column efficiency (the theoretical plate number is up to 37000 plates m(-1) in the case of inosine) in the separation of polar compounds, such as nucleosides and bases, organic acids, cephalosporins, and carbapenems.