文献类型：期刊文献

中文题名：兰索拉唑的合成工艺改进

英文题名：Process Improvement on the Synthesis of Lansoprazole

作者：俞小弟[1];金文虎[1];许煦[2];罗晓燕[1];冀亚飞[1]

机构：[1]华东理工大学药学院,上海200237;[2]华东理工大学化工学院,上海200237

年份：2007

卷号：15

期号：5

起止页码：647

中文期刊名：合成化学

外文期刊名：Chinese Journal of Synthetic Chemistry

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：兰索拉唑;缩合;氧化;过氧化氢;工艺改进

外文关键词：lansoprazole ; condensation; oxidation; hydrogen peroxide; process improvement

摘要：以甲醇钠为缩合剂,2-氯甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶盐酸盐与2-巯基苯并咪唑缩合,高收率(97%)地获得硫醚化合物(3);以过氧化氢-钼酸铵体系催化氧化3制得兰索拉唑,收率达81%。其结构经1H NMR和MS确证。
2-Chloromethyl-3-methyl-4-（2,2,2-trifluoroethoxy） pyridine hydrochloride and 2-mercaptobenzimidazole were condensed with sodium methoxide as a condensation agent in a high yield of 97% to afford a thioether compound, which was oxidize catalytically with the hydrogen peroxide -ammonium molybdate system to prepare Lansoprazole in a yield of 81%. Their structures were confirmed by ^1H NMR and MS.