文献类型：专利

英文题名：Process for preparing 4-(3-trifluoromethyl-5-(p-tolyl)-1H-pyrazolyl) benzene sulfonamide

作者：YU X;CHEN Z;SUN Y

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN1594296-A

申请日：2004-06-24

公开日：2005-03-16

语种：英文

收录：DERWENT

摘要：NOVELTY - The invention discloses a process for preparing type II epoxidation enzyme (COX-2) inhibiting agent 4-(3-trifluoromethyl-5-(p-tolyl)-1H-pyrazolyl) benzene sulfonamide (Celecoxib) by using 1-(p-cresyl)-4,4,4-trifluoro-1,3-butanedione and p-sulfamoyl phenylhydrazine hydrochlorate as raw material for reaction with homogeneous system comprising water and organic solvent including methanol or ethanol,ethylene glycol, propylene glycol, propanetriol, N, N-dimethyl formamide, N, N-dimethyl dimethylacetamide, 1-methyl-2-pyrrolidone, 1,3-dimethyl-3,4,5,6-tetrahydrochysene-2(1H)-pyrimidinone, 1,3-dimethyl-2-imidazolone, dimethyl sulfoxide, sulfolane, dioxane at room temperature.