文献类型：期刊文献

英文题名：Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid

作者：Li, Jianjun[1]; Fu, Yiwei[1]; Qin, Cong[1]; Yu, Yang[1]; Li, Hao[1]; Wang, Wei[1,2]

机构：[1] State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China; [2] Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM, 87131-0001, United States

年份：2017

卷号：15

期号：31

起止页码：6474

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20173304046531)

语种：英文

外文关键词：Cyclization

摘要：A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er. ? 2017 The Royal Society of Chemistry.