文献类型：期刊文献

英文题名：Rhodium-Catalyzed 1,4-Aryl Rearrangement of Sulfur Ylide for the Synthesis of 2-Pyridyl Thioethers

作者：Wang, Jie[1];Li, Qing -Yang[1];Wang, Shan -Shan[1];Wu, Xin-Yan[1];Li, Xingguang[1];Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2023

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000922285800001)】；

基金：? ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (Nos. 22201073, 21925201, and 22161160319) and the Fundamental Research Funds for the Central Universities. We thank the Research Center of Analysisand Test of East China University of Science and Technology for help in the characterization.

语种：英文

摘要：We report a novel rhodium-catalyzed rearrangement involving N-substituted 2-thiopyridones and diazoesters. This reaction proceeds through the rhodium-catalyzed formation of sulfur ylides, followed by a direct C-N bond cleavage to achieve N-to-C 1,4-pyridyl migration. The protocol can be used to construct various thiopyridines possessing tetrasubstituted carbon stereocenters in moderate to excellent yields, which expands the transformation pattern of sulfur ylide intermediates in rearrangement reactions.