文献类型：期刊文献

英文题名：Zwitterionic sulfobetaine-enabled suppression of cononsolvency in PNIPAM hydrogels

作者：Xu, Huixia[1];Zhang, Zekai[1];Lu, Hongyu[1];Han, Xia[1];Chen, Xueqian[2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China

年份：2026

卷号：304

期号：4

起止页码：919

外文期刊名：COLLOID AND POLYMER SCIENCE

收录：;EI(收录号：20260720056955);WOS:【SCI-EXPANDED(收录号:WOS:001680535700001)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (No. 22578114 and 22378112), Natural Science Foundation of Shanghai (No. 23ZR1415200) and Fundamental Research Funds for Central Universities (2022ZFJH04).

语种：英文

外文关键词：NIPAM; Zwitterion; Hydrogel; Cononsolvency; Thermo-response

摘要：Smart responsive polymers play a pivotal role in material development and biomedical applications. Focusing on the low critical solution temperature (LCST) property of thermally responsive N-isopropylacrylamide (NIPAM) hydrogel, this study introduces a zwitterionic monomer, sulfobetaine methacrylate (SBMA), to fine-tune the swelling properties and thermo/solvent responsive behaviors of P(NIPAM-SBMA) hydrogels. The innovative incorporation of SBMA imparts these hydrogels with superior swelling characteristics and broad temperature-responsive ranges, evidenced by a unique biphasic response to NIPAM content variation. A significant finding is the suppression of the cononsolvency effect in PNIPAM, traditionally observed in mixed methanol or ethanol-water solvents, upon SBMA integration. Molecular simulation was employed to analyze the affinity between various components, as well as the water adsorption capacities of NIPAM and SBMA units in copolymer hydrogels with different NIPAM/SBMA mass ratios. Combined with experimental results, the core mechanisms governing the swelling and cononsolvency behaviors of P(NIPAM-SBMA) hydrogels were explored. This work not only provides insights into the role of SBMA's zwitterionic nature in stabilizing the polymer network against solvent-induced collapse, but also paves the way for the design of stimuli-responsive hydrogels with tailored properties for advanced biomedical and material applications.