文献类型：期刊文献

中文题名：一类具有高水合常数的钆类核磁共振成像造影剂的研究

英文题名：A New Type of Magnetic Resonance Imaging Contrast Agents with High Hydration Numbers

作者：郝士婧[1];熊儒琳[1];程丽坤[1];胡爱国[1]

机构：[1]华东理工大学材料科学与工程学院,上海市先进聚合物材料重点实验室,上海200237

年份：2016

卷号：42

期号：1

起止页码：28

中文期刊名：华东理工大学学报(自然科学版)

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金(21274042)

语种：中文

中文关键词：氮氧化合物;钆(Ⅲ)配合物;核磁共振成像造影剂;纵向弛豫率;水合常数

外文关键词：N-oxides;gadolinium complexes;MRI contrast agents;longitudinal relaxivity;hydration numbers

摘要：合成了一类具有高水合常数(q)的钆类造影剂,该类配合物由金属钆与含有2个氮氧化基团和4个羧酸基团的有机配体组成,具有高水合常数的特点。通过核磁氢谱、碳谱以及高分辨质谱对配体及配合物的结构进行了表征。通过荧光寿命分析检测配合物的q值在3左右。该类配合物的纵向弛豫率(n)为8.5~10.1(mM)^-1·s^-1,约为商用造影剂二乙三胺五乙酸合钆(Gd-DTPA)的3倍。细胞实验证实该类造影剂具有很低的细胞毒性,这在临床应用中是非常关键的。该类配合物具有合成简便、弛豫率高以及毒性低等特点,为刺备更低成本、更高性能的造影剂打下基础。
A series of Gd(Ⅲ)complexes were synthesized and evaluated as potential magnetic resonance imaging(MRI)contrast agents.The ligands of these complexes are featured with two hyphenated amine-N-oxide and four earboxyl groups,providing the complexes with high hydration numbers(q,the number of inner-sphere water molecules).The structures of the ligands and complexes were characterized with 1H-NMR,13C-NMR and ESI-MS.Preliminary results on 1.5T MRI measurement of the complexes showed high rl values(longitudinal relaxivity)of 8.5--10.1(mM)-1·s-1.The q value of the complexes was determined as up to 3 with fluorescence lifetime analysis with their Eu(Ⅲ)analogues.Cell tests revealed low cytotoxicity of the complexes,which is essential for c simplicity,the high relaxivity and the low toxicity of the complexes linical applications.The structural provide a new solution for the development of highly efficient MRI contrast agents.