文献类型：期刊文献

中文题名：Preparation,Rheological Properties and Primary Cytocompatibility of TPU/PLA Blends as Biomedical Materials

英文题名：Preparation, Rheological Properties and Primary Cytocompatibility of TPU/PLA Blends as Biomedical Materials

作者：Hong Hua[1,2];Yang Lili[3];Yuan Yuan[1,2];Qu Xue[1,2];Chen Fangping[1,2];Wei Jie[1,2];Liu Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Changzheng Hosp, Dept Orthopaed Surg, Shanghai 200003, Peoples R China

年份：2016

卷号：31

期号：1

起止页码：211

中文期刊名：Journal of Wuhan University of Technology(Materials Science)

外文期刊名：JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION

收录：CSTPCD;;EI(收录号：20160701940945);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000377016700036)】；

基金：Funded by the Major State Basic Research Development Program of China (973 Program) (No. 2012CB933600), the National Natural Science Foundation of China (Nos. 81271705 and 83171383), the Major Program of Natural Science Foundation of Shanghai, China (No. 12JC1416302)

语种：英文

中文关键词：TPU PLA blends cytocompatibility biomedical devices

外文关键词：TPU; PLA; blends; cytocompatibility; biomedical devices

摘要：A polymer blends containing thermoplastic polyurethane（TPU） and poly（lactic acid）（PLA） as a biomedical material were prepared by a process of modifying thermally induced phase separation（MTIPS） and melt blending.The influences of composition,shear frequency,and temperature on the rheological behaviors of the blends were investigated by small amplitude oscillatory shear rheology.The results revealed that the addition of TPU into PLA significantly decreased the non-Newtonian index of the blends,and increased the sensitivity of the blends on shear rate,suggesting that optimization of the shear rate and temperature could improve the flowability of the blend melts in the extrusion process.In addition,the results of SEM images revealed that TPU distributed well into PLA matrix and showed good compatibility between the TPU and PLA,which made the blends with good toughness.The primary cytocompatibility of the blends was evaluated using C2C12 cells.The results suggested that the TPU/PLA blends did not affect cell growth,showing no cytotoxicity.In short,the TPU/PLA blends with excellent toughness had potential application as biomedical devices.
A polymer blends containing thermoplastic polyurethane (TPU) and poly (lactic acid) (PLA) as a biomedical material were prepared by a process of modifying thermally induced phase separation (MTIPS) and melt blending. The influences of composition, shear frequency, and temperature on the rheological behaviors of the blends were investigated by small amplitude oscillatory shear rheology. The results revealed that the addition of TPU into PLA significantly decreased the non-Newtonian index of the blends, and increased the sensitivity of the blends on shear rate, suggesting that optimization of the shear rate and temperature could improve the flowability of the blend melts in the extrusion process. In addition, the results of SEM images revealed that TPU distributed well into PLA matrix and showed good compatibility between the TPU and PLA, which made the blends with good toughness. The primary cytocompatibility of the blends was evaluated using C2C12 cells. The results suggested that the TPU/PLA blends did not affect cell growth, showing no cytotoxicity. In short, the TPU/PLA blends with excellent toughness had potential application as biomedical devices.