文献类型：期刊文献

英文题名：Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) and their oxidation-sensitive polymersomes

作者：Deng, Yangwei[1,2];Chen, Hui[1];Tao, Xinfeng[1,5];Trepout, Sylvain[4];Ling, Jun[2];Li, Min-Hui[1,3]

机构：[1]PSL Univ Paris, Inst Rech Chim Paris, CNRS, Chim ParisTech, F-75005 Paris, France;[2]Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China;[3]Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China;[4]Univ Paris Saclay, Inst Curie, Inserm US43, F-91405 Orsay, France;[5]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China

年份：2020

卷号：31

期号：7

起止页码：1931

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000548928800044)】；

基金：We acknowledge the French National Research Agency (No. ANR16-CE29-0028), the National Natural Science Foundation of China (No. 21674091) and the Joint Foundation of Shaanxi Province Natural Science Basic Research Program and Shaanxi Coal Chemical Group Co., Ltd. (No. 2019JLM-46) for financial support. Y. Deng thanks the China Scholarship Council for funding his Ph.D. scholarship in France. The authors would like to thank the PICT Ibisa for providing access to the cryo electron microscopy facility at Orsay.

语种：英文

外文关键词：Polypeptoid; Self-assembly; Polymersome; Oxidation-responsive; Glucose oxidase

摘要：Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) (PEG-b-PMeSPG) were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine N-thiocarboxyanhydride (MeSPG-NTA) initiated by amino-terminated PEG. The self-assemblies of three PEG-b-PMeSPG copolymers with different PMeSPG block lengths were first prepared by nanoprecipitation method using THE and DMF, respectively, as the organic solvent, and their morphologies were studied by Cryo-EM and DLS. To prepare polymersomes loaded with glucose oxidase (GOx), double emulsion method followed by extrusion treatment was employed. The oxidation-responsive disruption of polymersomes was achieved upon the introduction of glucose because of the oxidants generated insitu by GOx/glucose. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.