文献类型：期刊文献

英文题名：Avermectin induced vascular damage in zebrafish larvae: association with mitochondria-mediated apoptosis and VEGF/Notch signaling pathway

作者：Wang, Wei-Guo[1];Jiang, Xu-Feng[1];Zhang, Cheng[2];Zhan, Xiu-Ping[3];Cheng, Jia-Gao[1];Tao, Li-Ming[1];Xu, Wen-Ping[1];Li, Zhong[1];Zhang, Yang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]UT Southwestern Med Ctr, Dept Pathol, Dallas, TX 75390 USA;[3]Shanghai Agr Technol Extens Ctr, Shanghai 201103, Peoples R China

年份：2024

卷号：477

外文期刊名：JOURNAL OF HAZARDOUS MATERIALS

收录：;EI(收录号：20243216823662);WOS:【SCI-EXPANDED(收录号:WOS:001290470200001)】；

基金：This work was financially Sponsored by the National Key Research and Development Plan (2022YFD1700502, China) and the Fundamental Research Funds for the Central Universities (China).

语种：英文

外文关键词：Avermectin; Zebrafish larvae; Vascular toxicity; Mitochondrial damage; VEGF/Notch signaling pathway

摘要：Avermectin is a highly effective insecticide that has been widely used in agriculture since the 1990s. In recent years, the safety of avermectin for non-target organisms has received much attention. The vasculature is important organs in the body and participate in the composition of other organs. However, studies on the vascular safety of avermectin are lacking. The vasculature of zebrafish larvae is characterized by ease of observation and it is a commonly used model for vascular studies. Therefore, zebrafish larvae were used to explore the potential risk of avermectin on the vasculature. The results showed that avermectin induced vascular damage throughout the body of zebrafish larvae, including the head, eyes, intestine, somite, tail and other vasculature. The main forms of damage are reduction in vascular diameter, vascular area and vascular abundance. Meanwhile, avermectin induced a decrease in the number of endothelial cells and apoptosis within the vasculature. In addition, vascular damage may be related to impairment of mitochondrial function and mitochondria-mediated apoptosis. Finally, exploration of the molecular mechanisms revealed abnormal alterations in the expression of genes related to the VEGF/Notch signaling pathway. Therefore, the VEGF/Notch signaling pathway may be an important mechanism for avermectin-induced vascular damage in zebrafish larvae. This study demonstrates the vascular toxicity of avermectin in zebrafish larvae and reveals the possible molecular mechanism, which would hopefully draw more attention to the safety of avermectin in non-target organisms.