文献类型：期刊文献

中文题名：新型多羟基树枝化线形聚氨酯的合成

英文题名：Synthesis of novel polyhydric dendronized linear polyurethanes

作者：温礼濛[1];龚飞荣[1];赵燕超[1];杲云[1];饶炬[1];王耀先[1];程树军[1]

机构：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237

年份：2009

卷号：37

期号：6

起止页码：30

中文期刊名：化工新型材料

外文期刊名：New Chemical Materials

收录：北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家863项目(2007AA02Z450)

语种：中文

中文关键词：聚氨酯;树枝状分子;多羟基;生物相容性;亲水性

外文关键词：polyurethane,dendron,polyhydric,biocompatibility,hydrophilicity

摘要：聚氨酯侧链接枝末端含有大量羟基且具有良好生物相容性的脂肪族聚酯树枝状分子,在引入大量反应官能团的同时增加分子间空间间隔,为生物活性分子的接枝提供一种性能优异的中间材料。通过1H-NMR、DSC、接触角及表面分析等测试方法表征聚氨酯树枝化前后结构及性能的改变。结果显示,多羟基树枝化线形聚氨酯的氢键化程度大大提高,结晶性能降低,亲水性及表面粗糙度增加。细胞培养试验证明,该材料具有很好的细胞相容性,为其在生物医学上的应用奠定了良好的基础。
Novel polyhydric dendronized linear polyurethanes which can be used as intermediate materials for conjugation of bioactive molecules were successively synthesized through covalently immobilization of polyester dendrons at the side chains followed by a deprotection process of the acetonide groups. This method not only introduces lots of reactive groups but also grafts spacers between polymer chains. The structure of the polyester dendron immobilized polyurethane was characterized by ^1 H-NMR method. DSC analysis showed declined degree of crystallization in contrast with the unmodified polyurethane. The results of water contact angle test revealed improved hydrophilicity after modification. The formation of rough topographical features could be clearly seen on SEM photos. Meanwhile, endothelial cells culture showed improved cytocompatibility of dendronized polyurethanes than unmodified samples, which appears to be promising as a biocompatible material, consequently, as a potential carrier for biomacromolecules conjugation.