文献类型：期刊文献

英文题名：Controllable synthesis of spherical hydroxyapatite nanoparticles using inverse microemulsion method

作者：Ma, Xiaoyu[1,2];Chen, Yaying[2];Qian, Jiangchao[3];Yuan, Yuan[1,2,3];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2016

卷号：183

起止页码：220

外文期刊名：MATERIALS CHEMISTRY AND PHYSICS

收录：;EI(收录号：20164502989852);WOS:【SCI-EXPANDED(收录号:WOS:000386402100027)】；

基金：This work was supported by grants from the National Basic Research Program of China (973 Program, No. 2012CB933600), the 111 Project (B14018), the National Natural Science Foundation of China (No. 31271010, 31330028 and 31470924).

语种：英文

外文关键词：Microemulsion; Hydroxyapatite; Spherical nano particle

摘要：Spherical nanosized hydroxyapatite (HA) was successfully synthesized via a water-in-oil microemulsion route at room temperature in short time. The effect of water-to-oil and water-to-surfactant ratios on the stability of microemulsion system was investigated to establish a stable reaction system, with span-80, cyclohexane and Ca(NO3)(2)center dot 4H(2)O((NH4)(2)HPO4) solution as surfactant, oil phase, and water phase, respectively. Size and morphology change of obtained HA under optimal microemulsion system were further studied under various reaction time and temperature, and a possible growth mechanism was proposed. A moderate reaction temperature of 25 degrees C and reaction time of 5 h facilitated the formation of spherical HA particles in the dimension of 70 nm with good uniformity and regularity, which served as a great candidate in biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.