文献类型：期刊文献

英文题名：Efficient chiral separation enabled by ultrathin solvent-activated cyclodextrin membranes

作者：Yao, Hao[1,2];Wang, Dan[1,2];Tao, Haolan[3];Zhou, Linlong[1,2];Gu, Shuyun[1,2];Li, Siyao[1,2];Lian, Cheng[3];Xu, Zhi[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Shanghai Key Lab Multiphase Mat Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, State Key Lab Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2025

卷号：378

外文期刊名：SEPARATION AND PURIFICATION TECHNOLOGY

收录：;EI(收录号：20253719127511);WOS:【SCI-EXPANDED(收录号:WOS:001562488700002)】；

基金：This work was financially supported by National Key Research & Development Program of China (Grant No. 2024YFB3815600) , National Natural Science Foundation of China (Grant Nos. 22308099, 22478109, and 23FAA02066) , the open foundation of State Key Laboratory of Chemical Engineering (No. SKL-ChE-23B01) .

语种：英文

外文关键词：Free-interface interfacial polymerization; Chiral separation; Cyclodextrin membrane; Solvent activation; Ultrathin chiral nanofilm

摘要：Chiral separation membranes have demonstrated their significant potential for the efficient separation of racemic mixtures into enantiopure components. However, the preparation of membranes with both high enantioselectivity and flux remains a challenge. Herein, we adopted the free-interface interfacial polymerization strategy for fabricating ultrathin chiral amino-beta-cyclodextrin (CCD) membranes. By applying solvent-activated amino beta-cyclodextrin with superior chirality as the only reagent in aqueous phase, we successfully fabricated defect-free CCD enantioseparation membrane with sufficient chiral sites, exhibiting remarkable performance in separating racemic DL-phenylalanine, achieving an enantiomeric excess (ee %) value of 96.64 % and a flux of 1.01 mmol center dot m- 2 center dot h- 1. The unexpected performance of the CCD membrane is realized following a process of CD activation within dimethylformamide (DMF), during which the interaction with the solvent generates the appropriate structure changes. These changes enhance a binding energy difference between activated amino-beta-CD and enantiomers (D/L-phenylalanine) that is absent in the non-activated one, attributed to a differential hydrogenbond interaction state. The findings underscored the potential of integrating the chiral selectivity of cyclodextrin with the ultrathin properties of nanofilm to create efficient chiral separation membranes, thereby advancing the development of high-performance cyclodextrin-based materials for chiral separation.