文献类型：期刊文献

英文题名：Optimization of Electrode Configuration and Pulse Strength in Irreversible Electroporation for Large Ablation Volumes without Thermal Damage

作者：Yang, Yongji[1]; Moser, Michael[2]; Zhang, Edwin[3]; Zhang, Wenjun[1]; Zhang, Bing[4]

机构：[1] Tumor Ablation Group, CISR Center, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Surgery, University of Saskatchewan, Saskatoon, SK, S7N 0W8, Canada; [3] Division of Vascular and Interventional Radiology, Department of Medical Imaging, University of Toronto, Toronto, ON, M5T 1W7, Canada; [4] School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200072, China

年份：2018

卷号：1

期号：2

外文期刊名：Journal of Engineering and Science in Medical Diagnostics and Therapy

收录：EI(收录号：20230113346382)

语种：英文

外文关键词：Electrodes - Surface properties

摘要：The aim of this study was to analyze five factors that are responsible for the ablation volume and maximum temperature during the procedure of irreversible electroporation (IRE). The five factors used in this study were the pulse strength (U), the electrode diameter (B), the distance between the electrode and the center (D), the electrode length (L), and the number of electrodes (N). A validated finite element model (FEM) of IRE was built to collect the data of the ablation volume and maximum temperature generated in a liver tissue. Twenty-five experiments were performed, in which the ablation volume and maximum temperature were taken as response variables. The five factors with ranges were analyzed to investigate their impacts on the ablation volume and maximum temperature, respectively, using analysis of variance. Response surface method (RSM) was used to optimize the five factors for the maximum ablation volume without thermal damage (the maximum temperature ≤ 50 ℃ for 90 s). U and L were found with significant impacts on the ablation volume (P 3 without thermal damage can be obtained by using the following set of factors: U = 2362.2384 V, B = 1.4889 mm, D = 7 mm, L = 4.5659 mm, and N = 3. The study concludes that both B and N have insignificant impacts (P = 0.886, and P = 0.279, respectively) on the ablation volume; U has the most significant impact (P Copyright ? 2018 by ASME.