文献类型：期刊文献

英文题名：Crystallization of zinc lactate in presence of malic acid

作者：Zhang, Xiang-Yang[1];Fevotte, Gilles[2,3];Zhong, Liang[1];Qian, Gang[1];Zhou, Xing-Gui[1];Yuan, Wei-Kang[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Ecole Natl Super Mines, F-42023 St Etienne 2, France;[3]Univ Lyon 1, F-69100 Villeurbanne, France

年份：2010

卷号：312

期号：19

起止页码：2747

外文期刊名：JOURNAL OF CRYSTAL GROWTH

收录：;EI(收录号：20103613209448);WOS:【SCI-EXPANDED(收录号:WOS:000282349500020)】；

基金：This work has been supported by NSFC (20476026), 111 Project (B08021) and Open project of Skloche (SKL-ChE-08C08). The French research agency ANR is also acknowledged for the support granted to the project "IPAPI" (Improving the Properties of Active Pharmaceutical Ingredients), Ref. 07-BLAN-0183.

语种：英文

外文关键词：Impurities; Industrial crystallization; Purification; Zinc lactate; Malic acid

摘要：The influence of malic acid, which acts as an impurity on the cooling crystallization of zinc lactate is investigated in this paper by monitoring the relative supersaturation and the number of crystals during crystallization. The presence of malic acid increases the solution solubility and makes the metastable zone wider; it also changes the habit of the crystal. The purity of the final products is shown to be influenced by the amount and size of seed crystals, cooling rate, seeding temperature and final temperature, but appears to depend mainly on the particle size and level of supersaturation. Residual supersaturation thresholds are observed that depend on the final temperature. A model is proposed to predict the steady-state supersaturation value from the final temperature at a given impurity concentration. This model is based on Kubota and Gibbs equations. (C) 2010 Elsevier B.V. All rights reserved.