文献类型：期刊文献

英文题名：Osteoimmunomodulatory Nanoparticles for Bone Regeneration

作者：Wen, Jingyi[1];Cai, Donglin[2];Gao, Wendong[1];He, Ruiying[3];Li, Yulin[4];Zhou, Yinghong[5,6];Klein, Travis[1,6];Xiao, Lan[1,6];Xiao, Yin[1,2,6]

机构：[1]Queensland Univ Technol, Ctr Biomed Technol, Sch Mech Med & Proc Engn, Brisbane, Qld 4059, Australia;[2]Griffith Univ, Menzies Hlth Inst Queensland, Sch Med & Dent, Southport, Qld 4222, Australia;[3]Hubei Univ, Coll Chem & Chem Engn, Wuhan 430061, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat,State Key Lab Bioreactor Eng, Shanghai 200231, Peoples R China;[5]Univ Queensland, Sch Dent, Herston, Qld 4006, Australia;[6]Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med, Brisbane, Qld 4000, Australia

年份：2023

卷号：13

期号：4

外文期刊名：NANOMATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000941732700001)】；

基金：This research was supported by the Joint Research Centre Fund from the Department of Environment and Science (2019-2023), Queensland; Young Researcher Grant (19-066) from the Osteology Foundation, Switzerland, QUT Centre for Biomedical Technologies ECR/MCR grant scheme 2021.

语种：英文

外文关键词：nanoparticles; bone regeneration; osteoimmunomodulation; targeted drug delivery; nanomedicine

摘要：Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and immune cells to regulate bone formation and resorption. Osteoimmunology, studying this complicated process, has recently been used to develop biomaterials for advanced bone regeneration. Ideally, a biomaterial shall enable a timely switch from early stage inflammatory (to recruit osteogenic progenitor cells) to later-stage anti-inflammatory (to promote differentiation and terminal osteogenic mineralization and model the microstructure of bone tissue) in immune cells, especially the M1-to-M2 phenotype switch in macrophage populations, for bone regeneration. Nanoparticle (NP)-based advanced drug delivery systems can enable the controlled release of therapeutic reagents and the delivery of therapeutics into specific cell types, thereby benefiting bone regeneration through osteoimmunomodulation. In this review, we briefly describe the significance of osteoimmunology in bone regeneration, the advancement of NP-based approaches for bone regeneration, and the application of NPs in macrophage-targeting drug delivery for advanced osteoimmunomodulation.