文献类型：期刊文献

英文题名：GSH-Activatable NIR Nanoplatform with Mitochondria Targeting for Enhancing Tumor-Specific Therapy

作者：Yang, Guoliang[1];Chen, Chao[2];Zhu, Yucheng[1];Liu, Zhiyong[1];Xue, Yudong[1];Zhong, Sheng[1];Wang, Chaochao[1];Gao, Yun[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：11

期号：48

起止页码：44961

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20194807753845);WOS:【SCI-EXPANDED(收录号:WOS:000501620700004)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039 and 21875063) and Shanghai Sailing Program (No. 19YF1410900).

语种：英文

外文关键词：photodynamic therapy; GSH activatable; cyanine; mitochondria targeting; near infrared

摘要：Developing smart photosensitizers that are sensitive to tumor-specific signals for minimal side effects and enhanced antitumor efficacy is a tremendous challenge for tumor phototherapies. Herein, we construct a nanoplatform with glutathione (GSH)-activatable and mitochondria-targeted pro-photosensitizer encapsulated by ultrasensitive pH-responsive polymer for achieving imaging-guided tumor-specific photodynamic therapy (PDT). The GSH-activatable pro-photosensitizer, di-cyanine (DCy7), has been synthesized where two cyanine moieties are covalently conjugated by a disulfide bond, and the hydrophobic DCy7 is further encapsulated with an amphiphilic pH-responsive diblock copolymer POEGMA-b-PDPA to form P@DCy7 nanoparticles. Upon endocytosis by cancer cells, P@DCy7 nanoparticles dissociate at endosome first and then DCy7 is released to cytoplasm and subsequently activated by the high concentration of GSH, finally targets mitochondria for organelle-targeted PDT. Moreover, intracellular antioxidant GSH is consumed during the activation procedure that is beneficial to efficient PDT. These P@DCy7 nanoparticles display selective phototoxicity against tumor cells (HepG2 or 4T1 cells) over normal cells (BEAS-2B cells) in vitro, and their GSH-activatable enhanced PDT efficacy is further confirmed in tumor-bearing mice. Thus, P@DCy7 nanoparticles allow for accurate and highly efficient PDT with minimal side effects, providing an attractive nanoplatform for organelle-targeted precise PDT.