文献类型：期刊文献

英文题名：Preparation and antifouling property of polyurethane film modified by chondroitin sulfate

作者：Yuan, Huihui[1,3];Xue, Jing[1];Qian, Bin[1];Chen, Huaying[3,4];Zhu, Yonggang[4];Lan, Minbo[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]CSIRO Mfg, Private Bag 10, Clayton, Vic 3168, Australia;[4]Harbin Inst Technol Shenzhen, HIT Campus, Shenzhen 518055, Peoples R China

年份：2017

卷号：394

起止页码：403

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20164502998267);WOS:【SCI-EXPANDED(收录号:WOS:000389152900047)】；

基金：This research was supported by the National Natural Science Foundation of China (NSFC, contract No. 21304034). Dr. Yuan also acknowledges the support from CSIRO Manufacturing during her stay as a visiting scholar.

语种：英文

外文关键词：Polyurethane modification; Chondroitin sulfate; Protein adsorption; Glycosaminoglycan adhesion; Inorganic salt deposition

摘要：An antifouling polyurethane film modified by chondroitin sulfate (PU-CS) was prepared by chemical grafting with N-Boc-1,3-propanediamine as a spacer. The different mass fraction of N-Boc-1,3propanediamine was investigated to obtain PU-CS films with different CS grafting density. The surface properties of PU-CS films were comprehensively characterized. Proteins adsorption and glycosamino-glycans adhesion on films were evaluated. Moreover, inorganic salt deposition on film with highest CS grafting density (3.70 mu g/cm(2)) was briefly investigated. The results showed that the increase of CS grafting density improved not only the hydrophilicity but the antifouling performance of films. The best antifouling film reduced the adsorption of fibrinogen (BFG), human serum albumin (HSA) and lysozyme (LYS) by 81.4%, 95.0% and 76.5%, respectively, and the adhesion of chondroitin (CS), heparin (HP) and hyaluronic acid (HA) by 70.6%, 87.4% and 81.3%, respectively. In addition, the co-adsorption of proteins and glycosaminoglycans reduced up to 86.9% and 75.5%, respectively. Changes in inorganic salt deposition after co-adsorption of proteins and glycosaminoglycans on PU-CS(3) suggested that the proteins promoted the inorganic salt deposition, while glycosaminoglycans inhibited the crystal growth. The negatively charged polysaccharides might promote the generation of smaller crystals which could be conducive to provide theoretical and practical guide to develop novel urinary stents with significant anti-encrustation properties. (C) 2016 Elsevier B.V. All rights reserved.