文献类型：期刊文献

英文题名：Injectable Silver Nanoparticle-Based Hydrogel Dressings with Rapid Shape Adaptability and Antimicrobial Activity

作者：Zhao, Yuanyuan[1];Dai, Zhaobo[2];Huang, Huimin[1];Tian, Jia[2];Cai, Haibo[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, POB 309,130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2025

卷号：197

期号：2

起止页码：821

外文期刊名：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

收录：;EI(收录号：20243717030912);WOS:【SCI-EXPANDED(收录号:WOS:001309225900001)】；

语种：英文

外文关键词：Wound dressing; Hydrogel; Injectable; Silver nanoparticles; Antimicrobial

摘要：Burns and scalds often result in deep wounds that challenge adequate debridement and inflammation control using traditional sheet-like hydrogel dressings. Herein, we developed an antibacterial, injectable, and self-healing hydrogel (ADCM@Ag) by employing carboxymethyl chitosan (CMCS) for in situ green reduction of silver ions and utilizing a spontaneous Schiff base reaction with aldehyde-functionalized dextran (AD). SEM analysis revealed a porous structure within the hydrogel. Swelling and enzymatic degradation assays demonstrated that ADCM@Ag hydrogel possesses excellent fluid absorption capacity and biodegradability. Mechanical tests indicated good mechanical properties, allowing the hydrogel to withstand external forces when applied to animal wounds. The hydrogel exhibited good injectability, shape adaptability, and self-healing capability. Cell experiments showed that the ADCM@Ag hydrogel avoided the cytotoxicity caused by high concentrations of silver ions and had good cell compatibility. Antimicrobial assays showed that ADCM@Ag exhibited potent bactericidal effects against Gram-negative and Gram-positive bacteria, achieving at least 85% killing efficacy. Collectively, ADCM@Ag hydrogel has good potential for wound dressing applications.