文献类型：期刊文献

英文题名：A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human He la cervix carcinoma cells

作者：Shen, Ke[1];Sun, Liyun[1];Zhang, Huanying[1];Xu, Yufang[1];Qian, Xuhong[1];Lu, Yanhua[1];Li, Qi[2];Ni, Lei[3];Liu, Jianwen[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Dept Med Oncol, Shuguang Hosp, Shanghai 201203, Peoples R China;[3]Shanghai Jiao Tong Univ, Dept Respirat, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China

年份：2013

卷号：333

期号：2

起止页码：229

外文期刊名：CANCER LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000318838700012)】；

基金：This work was supported by the Shanghai Committee of Science and Technology (grant 11DZ2260600) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Oxidative stress; 7c; Lysosomes; Mitochondrion; Apoptosis

摘要：In this study, a novel naphthalimide derivative 7c was designed which is topo II inhibiting though owning weak DNA binders. It was shown that 7c could induce cancer cells apoptosis and have less cytotoxicity in normal human cell. Further investigations on Hela cells revealed that 7c could also induce ROS generation, lysosome rupture as well as cathepsin B release. Subsequent mitochondrial damages including mitochondrial membrane permeabilization and the release of cytochrome c were also found in 7c when treating with Hela cells. According to our data, 7c may act as a lead compound for potential anticancer drugs. The idea of naphthalimides modification may also provide a novel strategy for naphthalimides design. (C) 2013 Elsevier Ireland Ltd. All rights reserved.