文献类型：期刊文献

英文题名：Schizophrenic poly(ε-caprolactone)s: synthesis, self-assembly and fluorescent decoration

作者：Zhang, Jun[1];Xiao, Yan[1];Luo, Xueli[1];Wen, Lianlei[1];Heise, Andreas[2];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, 123 St Stephens Green, Dublin 2, Ireland

年份：2017

卷号：8

期号：21

起止页码：3261

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20172703890916);WOS:【SCI-EXPANDED(收录号:WOS:000402300400003)】；

基金：This work was supported by the National Natural Science Foundation of China (21674037), the National Key Research and Development Program (2016YFC1100703), and the Shanghai Scientific and Technological Innovation Project (14520720600).

语种：英文

外文关键词：Nuclear magnetic resonance spectroscopy - Alkalinity - Chemical modification - Ultraviolet visible spectroscopy - Dynamic light scattering - Micelles - Pyrene - Fluorescence - High resolution transmission electron microscopy - Self assembly

摘要：Double hydrophilic block copolymers (DHBCs) based on poly(e-caprolactone)s, poly(6-acetoxyl-epsilon-caprolactone)- b-poly(4-N-piperilactone) (PCCL-b-PPIL), were synthesized via ring-opening polymerization and deprotection. The self-assembly behaviour of these block copolymers in aqueous solutions was thoroughly explored via a combination of UV-vis spectroscopy, zeta potential measurement, H-1 NMR spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). It was observed that "schizophrenic" aggregations were formed and triggered by pH, i.e., the copolymers could self-assemble into PCCL-core micelles at acidic pH and PPIL-core micelles at alkaline pH. In addition, pendant groups in each block of copolymers facilitated further chemical modification with fluorescent dyes such as 1-(hydroxymethyl) pyrene and FITC. The fluorescence properties of pyrene-functionalized copolymers were closely related to their aggregate morphology, which could be adjusted simply by altering the environmental pH values. Meanwhile, it is expected that this novel type of degradable schizophrenic block copolymer holds potential application in stimuli-responsive fluorescent probes.