文献类型：会议论文

中文题名：IMPROVEMENT OF THE ERYTHROMYCIN A PURITY AND PRODUCTION BY GENETIC ENGINEERING IN S.ERYTHRAEA FERMENTATION

作者：QunFei Zhao[1];Qinglin Zhang[1];Zengliang Wang[1];Lin Chen[1];Hua Zhang[1];Wen Liu[1];

机构：[1]State Key Laboratory of Bioorganic and Natural Product Chemistry,Shanghai Institute of Organic Chemistry Chinese Academy of Science,Shanghai 200032,China State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;

会议论文集：15th International Symposiium on the Biology of Actinomycetes(第十五届国际放线菌生物学大会)论文集

会议日期：20090820

会议地点：上海

主办单位：中国微生物学会,中国农业生物技术学会,上海微生物学会

语种：英文

摘要：Erythromycin A (Er-A),produced by Saccharopolyspora erythraea,is one of important antibiotics with broad spectrum active against pathogenic Gram-positive bacteria.Its importance in infectious disease therapy is further highlighted by the fact that several Er-A based semi-synthetic derivatives known as the second and third generation products are commercially successful and widely used in the clinic.