文献类型：期刊文献

英文题名：One-pot synthesis of magnetite-loaded dual-mesoporous silica spheres for T2-weighted magnetic resonance imaging and drug delivery

作者：Luo, Xiaofeng[1];Niu, Dechao[1];Wang, Yao[1];Zhai, Yungang[1];Chen, Jianzhuang[1];Gu, Jinlou[1];Shi, Jianlin[1,2];Li, Yongsheng[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2015

卷号：5

期号：50

起止页码：39719

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20151900834708);WOS:【SCI-EXPANDED(收录号:WOS:000354211100012)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2012CB933602); Program for New Century Excellent Talents in University (NCET-10-0379); NSFC (Grant nos 51172070, 51132009, 51202068, 5141101086); Shuguang Project (11SG30); Chenguang Project (13CG25); the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Cytology - Mesoporous materials - Targeted drug delivery - Magnetic resonance imaging - Cancer cells - Controlled drug delivery - Medical applications - Nanomagnetics - Cells - Silica nanoparticles

摘要：The combination of mesoporous silica nanoparticles and superparamagnetic nanocrystals to fabricate multifunctional platforms presents great potentials for simultaneous imaging and drug delivery. In this work, we have successfully developed a simple one-step approach to synthesize magnetite-loaded dual-mesoporous silica spheres consisting of large pores in the core and small pores in the shell (Fe3O4@DMSSs) by embedding oil-soluble Fe3O4 into the large pores of DMSSs, which were prepared by employing polystyrene-b-poly(acrylic acid) (PS-b-PAA) and cetyl trimethyl ammonium bromide (CTAB) as dual-templates. The loading amounts of magnetite can be easily adjusted by varying the initial concentrations of Fe3O4 nanoparticles in the oil phase. The in vitro test indicates that Fe3O4@DMSSs possesses excellent T-2-weighted magnetic resonance (MR) imaging performance with a maximum T-2 relaxivity (r(2)) of 421.5 mM(Fe)-1 S-1. Furthermore, a high doxorubicin (DOX) loading capacity (65 wt%) was achieved and the obtained DOX-loaded Fe3O4@DMSSs (DOX/Fe3O4@DMSSs) exhibits pH-sensitive behaviour with accelerated release of DOX in acidic environment. Confocal laser scanning microscopy observation shows that DOX/Fe3O4@DMSSs was able to locate in the cytoplasm of MCF-7 cells and release DOX into the nucleus to kill cancer cells. Therefore, it is anticipated that Fe3O4@DMSSs can be promising candidates as both T-2-weighted MR contrast agents and drug delivery carriers in further biomedical applications.