文献类型：期刊文献

英文题名：Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

作者：Yang, Yunlong[1];Zhang, Jieyuan[2];Liu, Zhenzhen[1];Lin, Qiuning[1];Liu, Xiaolin[2];Bao, Chunyan[1];Wang, Yang[2];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Orthoped Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China

年份：2016

卷号：28

期号：14

起止页码：2724

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20160902018003);WOS:【SCI-EXPANDED(收录号:WOS:000373839600006)】；

基金：Y.Y. and J.Z. contributed equally to this work. This work was supported by NSFC (21425311, 21421004, 51273064, 51403061), the Postdoctoral Fund in China (2015T80405) and the Fundamental Research Funds for the Central University. All procedures for animal experiments were approved by the Animal Research Committee of the School Medicine at Shanghai Jiao Tong University.

语种：英文

外文关键词：Tissue engineering - Hyaluronic acid - Crosslinking - Tissue - Biocompatibility - Hydrogels - Amines

摘要：A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine. ? 2016 Wiley-VCH Verlag GmbH & Co. KGaA.