文献类型：期刊文献

英文题名：Azobenzene-benzoylphenylureas as photoswitchable chitin synthesis inhibitors

作者：Tian, Xue[1];Zhang, Chao[1];Xu, Qi[1];Li, Zhong[1];Shao, Xusheng[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：15

期号：15

起止页码：3320

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20171603584377);WOS:【SCI-EXPANDED(收录号:WOS:000399201000028)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21372079, 21472046), Shanghai Pujiang Program (14PJD012) and Science and Technology Commission of Shanghai Municipality (16391902300).

语种：英文

外文关键词：Azobenzene - Insecticides

摘要：Benzoylphenylureas (BPUs) are used as synthetic insect growth regulators for inhibiting chitin synthesis. Merging insecticidal BPUs with photoswitchable azobenzene generated photoresponsive chitin synthesis inhibitors. A prepared azobenzene-benzoylphenylurea can be activated upon irradiation with UV light, and shows 6-fold and 2-fold activity difference to armyworm (Mythimna separata) and German cockroach (Blattella germanica) sulfonylurea receptors, respectively. This is the first example of a photoswitchable BPU insecticide. The generation of such a photoresponsive BPU insecticide allows for modulation of the insecticidal activity by light, and may facilitate the spatiotemporal control over the sulfonylurea receptor and the mechanistic study of this kind of insecticide.