文献类型：期刊文献

中文题名：嗅球中神经元间的相互作用及同步运动分析

英文题名：Interaction between different cells in an olfactory bulb and synchronous kinematic analysis

作者：徐爱蕾[1];杜莹[2];王如彬[2]

机构：[1]华东理工大学信息科学与工程学院,上海200237;[2]华东理工大学理学院,上海200237

年份：2013

卷号：32

期号：2

起止页码：175

中文期刊名：振动与冲击

外文期刊名：Journal of Vibration and Shock

收录：CSTPCD;;EI(收录号：20131016087601);Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家自然科学基金重点项目(11233005)

语种：中文

中文关键词：嗅球;僧帽细胞;颗粒细胞;网络建模;同步性

外文关键词：olfactory bulb ; mitral cell ; granule cell ; network modeling ; synchronization

摘要：嗅球对嗅觉信息的处理是嗅觉系统信号编码的一个重要环节,其中兴奋性的僧帽细胞(Mitral Cell,MC)与抑制性的颗粒细胞(Granular Cell,GC)的相互作用尤为关键。本文首先介绍了嗅觉系统网络中关于同步振荡的研究现状,然后建立嗅球中僧帽细胞及颗粒细胞的动力学模型,仿真得到了单个僧帽细胞、颗粒细胞以及僧帽细胞与颗粒细胞在耦合条件下神经元的发放模式。结果表明,僧帽细胞对颗粒细胞有兴奋性作用,而颗粒细胞对僧帽细胞有抑制性作用,细胞放电序列随着突触连接强度的改变而改变。此外,建立简单的嗅觉网络模型,分析了当颗粒细胞分别构成环形和网格状两种拓扑结构时,不同网络对两个僧帽细胞同步性的影响,用同步性指标ISI-distance刻画同步程度。数值分析表明颗粒细胞网格状的拓扑结构对僧帽细胞的同步性作用更为明显一些。
Olfactory bulb plays an important part in signal encoding of an olfactory system. The interaction between excitatory mitral cells and inhibitory granule cells is particularly crucial. Here, the current situation of synchronous oscillation in the network of an olfactory system was firstly introduced. Then, the dynamic models of a mitral cell and a granular cell in the olfactory bulb were built. The simulation figures showed the firing patterns of a single mitral cell, a single granular cell, and these two kinds of cells having a coupling relationship. The results indicated that mitral cells have an excitatory effect on granular cells, and granular cells have an inhibitory effect on mitral cells; the firing pattern varies with different synaptic strength. In addition, simple olfactory network models were built, the influence of ring-like and grid-like neuronal network of granular cells on the synchronization of two mitral cells was analyzed. Different types of firing synchronization were diagnosed by means of ISI-distanee method. The numerical analysis indicated that grid-like neuronal network of granular cells can make mitral cells synchronize better.